National Physical Therapy Examination (NPTE) Practice Exam

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What is a possible side effect of medications used to improve bone strength in patients with Paget's disease?

Impaired blood-clotting times
Swelling of the feet or abdomen
Dizziness and lightheadedness
Hypotension

The correct answer is: Impaired blood-clotting times

Medications used to improve bone strength in patients with Paget's disease often include bisphosphonates and calcitonin. These medications can have several side effects due to their mechanism of action on bone metabolism. Impaired blood-clotting times can be associated with certain bisphosphonates, particularly if they affect calcium metabolism or interact with other coagulation processes in the body. When considering Paget's disease treatment, these medications influence bone resorption and deposition, which might indirectly affect how well certain minerals required for proper blood clotting are balanced in the body. Therefore, any disruptions in calcium homeostasis or changes in vitamin K metabolism (which plays a critical role in clotting) can potentially lead to impaired blood-clotting times. This side effect is a significant consideration for healthcare providers when prescribing these medications, as it emphasizes the importance of monitoring patients for any complications related to their treatment. Understanding these effects can help in managing overall patient care and ensuring safe medication practices.