National Physical Therapy Examination (NPTE) Practice Exam

What antibacterial agent is considered most effective for infection control in cases of full thickness burn with thick eschar?

1. Sulfamylon

2. Nitrofurazone

3. Panafil

4. Silver nitrate

The correct answer is: Sulfamylon

Sulfamylon, also known as mafenide acetate, is particularly effective in the management of burn wounds, especially full thickness burns with thick eschar. This agent has broad-spectrum antibacterial properties, which makes it capable of fighting against a wide range of Gram-positive and Gram-negative bacteria, including those that are commonly found in burn wounds. One of the significant advantages of Sulfamylon is its ability to penetrate eschar, the tough and necrotic tissue that forms over deep burns. This penetration is crucial because the eschar can harbor bacteria and prevent effective treatment. Unlike some other agents, Sulfamylon can diffuse into the eschar, allowing it to eliminate bacteria that may be present beneath the surface. Additionally, Sulfamylon is effective in controlling infections in the presence of burn injuries due to its ability to help prevent the onset of systemic infections, which are a common complication of extensive burns. Its action is especially critical in full thickness burns where the risk of infection is heightened due to the depth and severity of the tissue damage. While other agents like nitrofurazone, Panafil, and silver nitrate may be effective in certain circumstances, they do not have the same level of efficacy against eschar or broad-spectrum bacteria in the